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Type 2 Diabetes Remission

Proving the 'impossible', possible.

Virta Health

Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes

Shaminie J. Athinarayanan, Sarah J. Hallberg, Amy L. McKenzie, Katharina Lechner, Sarah King, James P. McCarter, Jeff S. Volek, Stephen D. Phinney & Ronald M. Krauss Cardiovascular Diabetology volume 19, Article number: 208 (2020)


Conclusion: Consumption of a very low carbohydrate diet with nutritional ketosis for 2 years in patients with type 2 diabetes lowered levels of small LDL particles that are commonly increased in diabetic dyslipidemia and are a marker for heightened CVD risk. A corresponding increase in concentrations of larger LDL particles was responsible for higher levels of plasma LDL-C. The lack of increase in total LDL particles, ApoB, and in progression of CIMT, provide supporting evidence that this dietary intervention did not adversely affect risk of CVD.
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Diversa Health

A Health Care Professional Delivered Low Carbohydrate Diet Program Reduces Body Weight, Haemoglobin A1c, Diabetes Medication Use and Cardiovascular Risk Markers—A Single-Arm Intervention Analysis

Grant D. Brinkworth, Thomas P. Wycherley, Pennie J. Taylor and Campbell H. Thompson


Conclusion: The present results indicate that an HCP delivered LC diet program can facilitate clinically relevant weight loss and improved blood glucose control in individuals who are overweight or obese and/or with elevated blood glucose levels. This resulted in an overall reversion across obesity and glycaemic levels for diabetes classifications and reductions in diabetes medication use.
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Norwood Surgery

Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years

David Unwin, Ali Ahsan Khalid, Jen Unwin, Dominic Crocombe, Christine Delon, Kathy Martyn, Rajna Golubic, and Sumantra Ray

Conclusion: For those choosing a lower carbohydrate dietary approach for an average of 23 months it is possible to achieve a 46% drug-free T2 diabetes remission rate in UK primary care whilst also achieving significant improvements in weight, blood pressure and lipid profiles. In patients with prediabetes (HbA1c 42 to 48 mmol/mol), a LCD approach reduced HbA1c to within a non-diabetic threshold in 93% of patients. Our audit showed participants who started with the worst blood sugars (HbA1c) saw the greatest improvements in diabetic control.

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Polycystic Ovarian Syndrome & Fertility

Low carbohydrate, ketogenic, and high protein approaches to treating PCOS & improving fertility. 

International Journal of Endocrinology

The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials

Conclusion: Based on the current evidence, LCD, particularly long-term LCD and low-fat/low-CHO LCD, may be recommended for the reduction of BMI, treatment of PCOS with insulin resistance, prevention of high LDL-C, increasing the levels of FSH and SHBG, and decreasing the level of T level. Together, the analyzed data indicate that proper control of carbohydrate intake provides beneficial effects on some aspects of PCOS and may represent one of the important interventions improving the clinical symptoms of affected patients.
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J Obstet Gynaecol Res

Ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese: A randomized, open-label, parallel-group, controlled pilot trial

Conclusions: In addition to improving the menstrual cycle, KD had the additional benefits of reducing blood glucose and body weight, improving liver function, and treating fatty liver compared to traditional pharmacological treatment in women with PCOS and liver dysfunction who were obese.
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Clinical Endocrinology

Favourable metabolic effects of a eucaloric lower-carbohydrate diet in women with PCOS

Conclusions: Paired t-test indicated that the lower-CHO diet induced significant decreases in basal β-cell response (PhiB), fasting insulin, fasting glucose, HOMA-IR, total testosterone and all cholesterol measures, and significant increases in insulin sensitivity and dynamic (‘first-phase’) β-cell response. The STD diet induced a decrease in HDL-C and an increase in the total cholesterol- to-HDL-C ratio. Across all data combined, the change in testosterone was positively associated with the changes in fasting insulin, PhiB and insulin AUC (P < 0·05). In women with PCOS, modest reduction in dietary CHO in the context of a weight-maintaining diet has numerous beneficial effects on the metabolic profile that may lead to a decrease in circulating testosterone.
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Insulin resistance & Metabolic Health

Blood parameters & cardiovascular risk.

American Journal of Clinical Nutrition

Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia—a randomized controlled feeding trial

Conclusions: A low-carbohydrate diet, high in saturated fat, improved insulin-resistant dyslipoproteinemia and lipoprotein(a), without adverse effect on LDL cholesterol. Carbohydrate restriction might lower CVD risk independently of body weight, a possibility that warrants study in major multicentered trials powered on hard outcomes. 
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Journal of Clinical Medicine

Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss

Conclusion: Consistent with the perspective that MetS is a pathologic state that manifests as dietary carbohydrate intolerance, these results show that compared with eucaloric high carbohydrate intake, LC/high-fat diets benefit MetS independent of whole-body or fat mass. 
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Progress in Lipid Research

Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome

Conclusions: The results of several prospective low-carbohydrate diet studies have been presented that point to a consistent improvement in traditional features of MetS. Metabolic syndrome consists of additional features related to defective insulin action including inflammation and altered fatty acid partitioning. The role of dietary carbohydrate in contributing to these emerging aspects of MetS has been presented. The preponderance of evidence indicates that restricting dietary carbohydrate positively impacts fatty acid composition and inflammation, even when the isocaloric replacement of dietary carbohydrate by fat increases ones intake of SFA. 
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Heartburn & GORD

Improvements in heart burn symptoms due to dietary composition, hormonal changes & weight loss.

Alimentary Pharmacology and Therapeutics

Dietary carbohydrate intake, insulin resistance andgastro-oesophageal reflux disease: a pilot study in European-and African-American obese women.

Conclusions: GERD symptoms and medication usage was more prevalent in European-American women, for whom the relationships between dietary carbohydrate intake, insulin resistance and GERD were most significant. Nevertheless, high-fat/low-carbohydrate diet benefited all women with regard to reducing GERD symptoms and frequency of medication use.
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Digestive Diseases and Sciences

A Very Low-Carbohydrate Diet Improves Gastroesophageal Reflux and Its Symptoms.

Conclusions: These data suggest that a very low-carbohydrate diet in obese individuals with GERD significantly reduces distal esophageal acid exposure and improves symptoms.
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Increasing insulin resistance is associated with increasedseverity and prevalence of gastro-oesophageal reflux disease.

Conclusions: Our findings demonstrate clear associations between insulin resistance, metabolic syndrome and GERD. Whether reducing insulin resistance may improve GERD symptoms or EO deserves prospective study
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+ coming soon

  • Weight loss 
  • Blood pressure
  • Migraines
  • Autoimmunity