The hormones GLP-1, PYY, and ghrelin play important roles in the satiating effects of protein. In response to protein intake, levels of GLP-1 and PYY increase, while ghrelin decreases. GLP-1 and PYY are considered anorexigenic, meaning they reduce appetite and decrease the desire to eat. Ghrelin, on the other hand, is orexigenic, meaning it increases appetite and promotes weight gain.